I. Layout and Flow Design
Plan Layout: The workshop is typically divided into clean zones, quasi-clean zones, and auxiliary zones. Common layouts include:
(1) Peripheral Corridor Type: The outer corridor serves for observation and equipment placement; exterior windows must use double-layer sealed windows.
(2) Internal Corridor Type: Cleanrooms are located on the periphery with the corridor inside. The corridor maintains a high cleanliness level, sometimes equivalent to the cleanrooms.
(3) End-to-End & Core Types: Depending on the production process, clean zones and auxiliary rooms are placed at opposite ends, or the clean zone is placed at the core to shorten pipelines and reduce heating/cooling energy consumption.
Personnel Flow: Before entering the clean zone, personnel must undergo a "personnel purification" process, including changing shoes, changing clothes, air showering, and disinfection. Changing rooms must maintain positive pressure, while toilets and showers should maintain negative pressure to prevent contamination.
Material Flow: Materials must undergo "material purification" and follow a route separate from personnel. If a shared entrance is unavoidable, separate doors must be used, and materials must undergo coarse purification first. A direct route is used for strong production lines, while an intermediate storage room can be set up for weaker lines. The coarse and fine purification stages should maintain negative or zero pressure relative to the clean zone due to high dust generation.
II. Pipeline Organization and Concealed Works
Cleanroom pipelines are complex and require concealed installation, with internal surfaces treated according to cleanliness standards:
Technical Interstitials: Divided into top interstitials and room technical interstitials.
Technical Shafts (Walls): Used for vertical pipelines and auxiliary equipment unsuitable for the cleanroom. They mostly use lightweight partitions to facilitate future process adjustments.
Technical Shafts (Vertical): Serve as permanent vertical passages across floors. For fire safety, interlayers must be sealed with fire-resistant materials, and fire doors must be installed.
III. Plant Room Location and Safety Evacuation
Plant Room Siting: The HVAC plant room should be close to workshops with large air supply volumes to shorten ductwork. Structural separation or dispersed layouts are required to isolate noise and vibration. Vibration isolation for equipment and sound absorption/insulation measures for walls must be implemented inside the plant room.
Safety Evacuation: Given the high airtightness of cleanrooms, safety evacuation is critical:
(1) Exit Setup: Each fire zone or clean zone on every floor must have at least two safety exits.
(2) Regulations: Personnel purification entrances must not serve as evacuation exits. Bypass doors are required for air showers, and daily entry/exit should use these bypass doors.
(3) Door Opening Direction: To balance indoor positive pressure maintenance with emergency evacuation needs, safety evacuation doors between clean/non-clean zones and between clean zones/outdoors must always open in the direction of evacuation.
Suzhou Pharma Machinery Co.,Ltd.
2026/10/19
Icey
